Monkey Majik adalah band Jepang terdiri dari dua bersaudara Kanada, Maynard dan Blaise Plant, yang keduanya adalah vocals dan gitar, drummer tax dan bassist Dick . Band yang kadang-kadang disebut sebagai “hibrida-band”, karena setengah dari anggota adalah orang asing dan lirik yang dinyanyikan dalam bahasa Inggris dan Jepang.
Sebagian besar dari musik band lintas telah dipromosikan melalui program televisi, commercials, dan film. Band telah dipilih sebagai “Duta Goodwill” untuk ulang tahun ke-80 relation jepang kanada
Maynard Plant dipindahkan ke Jepang pada tahun 1997 [2] untuk mengajar Bahasa Inggris setelah lulus dari Queen’s University di mana dia adalah presiden dari Alma Mater Society. Dia bisa bekerja sambil belajar Jepang sebagai Asisten Guru Bahasa. Blaise pindah ke Jepang pada tahun 2001 untuk melanjutkan band ini, setelah belajar drama di University of Lethbridge di Alberta dan menghabiskan beberapa waktu sebagai solo-artist. Logat jepangnya datang dengan cepat sebagai hasil dari hafalan lagu Jepang. Band dimulai sebagai hobi tetapi dengan cepat berubah serius pada tahun 2001 ketika mereka merilis EP pertama mereka yang disebut TIRED, pengatur dibiayai terbatas pada rilis 1000 copy tersedia di Tower Records di Sendai. EP yang dicapai pada posisi nomor satu penjualan untuk toko langsung selama enam bulan. Pada tahun 2002, mereka menandatangani dengan label rekaman UNDER Horse Records. Pada tahun 2003 band dirilis pertama full-length album “Spade”, sekali lagi hanya tersedia di Tower Records di Sendai. Album tetap nomor satu di posisi-toko penjualan untuk 13 bulan berturut-turut. “Spade” dirilis nasional pada tahun 2004. Band kedua panjang album, “eastview”, dirilis pada 2005. Pada musim gugur tahun yang sama band ditandatangani pada label besar avex.
Single pertama mereka merilis single melalui avex adalah “terbang” di tahun 2006. Single komersial yang telah berhasil, mencapai # 19 di Oricon chart. “Fly” dengan cepat diikuti dengan rilis single kedua mereka, “Around the World”, yang telah digunakan sebagai drama Seiyuuki dari tema lagu. “Around the World” mereka lolos menjadi satu, mencapai # 4 di Oricon grafik dan charting untuk 13 bulan. “Around the World” terjual 164.299 copy di tahun 2006, menjadi 62. Paling menjual dari satu tahun di Jepang.
Pada tahun 2007 mereka merilis Monkey Majik keempat panjang album “Sora wa maru de”, dimana lagu berjudul “Sora wa maru de” menjadi lagu pertama di Jepang Sejarah mencapai # 1 di USEN Permintaan Lagu sebelum dilepaskan. Sejak “TIRED” band telah menjual setiap tempat di Jepang, dan sering dianggap sign autographs .
Album mereka yang terbaru “TIME” membuka minggu pertama di # 2 di Oricon Chart.
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Exposure to phthalates during pregnancy can affect a newborn’s brain development, study finds
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Phthalates — the synthetic chemicals used in everyday products for food packaging, personal care, toys and more — have been linked to abnormal neurological development in infants.
Now, scientists may have discovered a biological pathway for how this phenomenon could occur. Researchers found that in utero exposure to phthalates is linked with altered metabolism of neurotransmitters and amino acids involved in brain maturation, according to a study published Wednesday in the journal Nature Communications.
The report is the first to use untargeted metabolomics — the study of all small molecules or metabolites in a biological system — to connect a mother’s phthalate exposure to a newborn’s metabolites, and those metabolites to neurological development, said senior study author Dr. Donghai Liang via email.
“This represents an important step forward in understanding how prenatal chemical exposures shape infant development at the molecular level,” added Liang, an associate professor of environmental health at Emory University’s Rollins School of Public Health in Atlanta.
First introduced in the 1920s, phthalates are used to make plastics softer and more flexible, primarily in polyvinyl chloride (PVC) products such as vinyl flooring, medical devices, children’s toys, food packaging or shower curtains. The chemicals also help lubricate substances and carry fragrances in various personal care products including deodorant; nail polish; perfumes; hair gels, sprays or shampoos; soaps; and body lotions.
Phthalates are also endocrine disruptors that have been linked to preterm birth, infant genital abnormalities, childhood obesity, asthma, cancer, cardiovascular issues, and low sperm count and testosterone in men.
“We conducted this study because phthalates are everywhere in our daily lives,” Liang said, hence their nickname “everywhere chemicals.”
Harming infant health
The findings are based on mother-newborn pairs enrolled in the Atlanta African American Maternal-Child Cohort between 2016 and 2018. In urine samples collected from 216 mothers between eight weeks and 14 weeks of gestation at visit one and 145 participants between 24 and 30 weeks’ gestation at visit two, the authors measured eight phthalate metabolites. Participants were around age 24 on average, and their levels of some phthalate metabolites were higher than the average determined by the National Health and Nutrition Examination Survey.
Within a day or two of birth, the authors collected the babies’ blood via a heel stick.
The team found prenatal phthalate levels were associated with lower levels of tyrosine, an amino acid and precursor to the thyroid hormone thyroxine. Thyroxine was also abnormally low in those with in utero phthalate exposure, and low thyroxine has been previously associated with greater vulnerability to illness and neurodevelopmental issues in newborns, the authors said. Tyrosine is also a precursor to the neurotransmitters dopamine, norepinephrine and epinephrine, all of which partly contribute to the body’s fight-or-flight response. Low levels of these neurotransmitters can lead to various problems, including anxiety, depression and trouble focusing.
Prenatal phthalate exposure was also linked with lower levels of the essential amino acid tryptophan, which converts into 5-hydroxytryptophan (or 5-HTP), which then turns into serotonin. Both 5-HTP and serotonin were also low. Serotonin has several critical roles in the body, including mood regulation, sleep, learning, memory, digestion and the body’s response to stress. Previous research has linked low serotonin with mood disorders such as depression and anxiety, sleep problems, and digestive issues.
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